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KMID : 0380020030180030207
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Korean Journal of Biotechnology and Bioengineering
2003 Volume.18 No. 3 p.207 ~ p.210
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Screening of Potential Compounds Promoting BDNF Production in Noradrenergic Locus Coeruleus Neurons
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Jeon Hong-Sung
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Abstract
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The locus coeruleus (LC) contains about half of the total number of noradrenergic neurons in the brain and those noradrenergic neurons from the LC innervate entire brain regions. The LC is a major common target region in several neurodegenerative disorders such as Alzheimer’s, Pakinson’s and Huntington’s diseases. The brain-derived neurotrophic factor (BDNF) regulate neuronal cell survival and differentiation of central nervous system neurons, including LC noradrenergic neurons. In this study, various small molecules and growth factors were tested as candidates to promote the production of BDNF in LC noradrenergic neuronal cells. The molecules tested include neuropeptides, cytokines, growth factors, neurotransmitters, and intracellular signaling agents. Four small molecules or growth factors, FGF8b, BMP-4, forskolin, and dibutyryl cGMP, were found to increase the release of BDNF in LC noradrenergic neurons. Especially, BMP-4 significantly enhanced BDNF production over 2.5-fold in LC noradrenergic neurons.
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KEYWORD
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Locus coeruleus, BDNF, BMP-4, FGF8b, forskolin
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